New study linking periodontal disease to macular degeneration in mouse models. Further research is on going.
Investigating the enigmatic link between periodontal inflammation and retinal degeneration
INTERNATIONAL & AMERICAN ASSOCIATIONS FOR DENTAL RESEARCH
Alexandria, VA, USA – At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Hyun Hong, The Dental College of Georgia at Augusta University, presented a poster titled “Investigating the Enigmatic Link Between Periodontal Inflammation and Retinal Degeneration.” The AADR/CADR Annual Meeting is in Fort Lauderdale, Fla., USA from March 21-24, 2018.
Many clinical studies link Chronic Periodontitis (CP) to various systemic disorders and lately age-related macular degeneration (AMD), a leading cause of irreversible vision loss in elderly, is found to be associated with periodontal disease. The keystone oral-pathobiont and one of the major causative organism for CP, Porphyromonas gingivalis (Pg), has been identified with the ability to invade epithelial, fibroblasts and dendritic cells. “Our study was designed with an objective to interrogate the role of Pg and its fimbriae-mediated infection of human retinal-pigment epithelial cells and retro-orbitally injected mice retina, thus revealing possible molecular links between CP and AMD,” said Hyun Hong (Predoctoral dental student, Summer Research Program, Dental College of Georgia) and Dr. Pachiappan Arjunan, the Principal Investigator, who directed this study (Assistant Professor, Department of Periodontics, Dental College of Georgia, Augusta University).
Human retinal-pigment epithelial cells were infected with Pg and its isogenic mutant strains and genes were analyzed by qPCR.
The results showed that human retinal-pigment epithelial cells take up Pg381 and that qPCR shows a significant increase in expression levels of genes, important in immunosuppression and angiogenesis/neo-vascularization markers compared with uninfected control.Certain complement regulatory-related genes were upregulated, while others were downregulated.
In a mouse model, AMD-related effects on mouse retinae were induced by Pg-injection compared to control group…..