Long-Term NSAID Use May Be Protective in AMD
by: Amanda Warren
A study examining the relationship between nonsteroidal anti-inflammatory (NSAID) use and age-related macular degeneration (AMD) has determined that long-term use of NSAID is associated with lower risk of exudative, commonly referred to as wet, AMD (wAMD).
Lead author Bobeck S. Modjtahedi, MD, with the Department of Ophthalmology and Eye Monitoring Center at Kaiser Permanente Baldwin Park Medical Center in California, and colleagues in the Kaiser Permanente System, stated that although their study determined that the “overall impact of NSAIDS on AMD is small,” the reduced risk of wAMD associated with long-term NSAID users “may point to a protective effect and deserves further study as a possible mechanism to modulate disease risk.”
The prospective cohort study on NSAID and AMD included 51,371 participants in the California Men’s Health Study (CMHS) conducted by Kaiser Permanente. Of the total participants, 292 were diagnosed with wAMD and 1536 with non-exudative, or dry, AMD. The CMHS included men between the ages of 45 and 69 years old.
Participants were asked to complete a baseline questionnaire in 2002–2003 which included sociodemographic data, personal and family health history, health conditions, medication use, tobacco and alcohol use, and healthcare utilization, and received a follow-up survey in 2006 (mean time to follow-up, 7.4 years). Information on AMD diagnosis post-initial survey was retrieved via electronic medical records in the Kaiser Permanente system. Patients reporting AMD as diagnosed health condition in the baseline questionnaire were excluded from the study.
Modjtahedi and colleagues characterized participants as NSAID users based on long- and short-term use indications on the survey. The total number of NSAID users among the study population was 16.4% (n = 8431) short-term users, 20.5% (n = 10,554) long-term users, and 13.6% (n = 7012) former users. The researchers also collected data on long- and short-term aspirin users, specifically finding that among the study population, 13.6% (n = 6997) were short-term, 14.3% (n = 7352) were long-term users, and 7.9% (n = 4057) were former users……
Source: MD Magazine