AMD is all about genetics. A simple test can remove the risk- You can find the test here: http://macularisk.com/– we are working diligently to get Medicare to cover this test.- MDA
Age-related macular degeneration results from a combination of genetic and environmental factors. … Genetic changes in and around several complement system genes, including the CFH gene, contribute to a person’s risk of developing age-related macular degeneration.-NIH
Patients with certain genetic variants are at greater risk for AMD progression
MIAMI — Age, phenotype characteristics and genetic variants can put patients at greater risk for progression of age-related macular degeneration.
“We want to develop drugs, and our future studies should be very concentrated on the transition from intermediate into late AMD and to find biomarkers,” Carel B. Hoyng, MD, said at Angiogenesis, Exudation, and Degeneration 2017.
Using the EUGENDA database, 254 patients with early or intermediate AMD and 5-year follow-up data were identified. Of these patients, 54 progressed to late-stage AMD at 5 years, for a progression rate of more than 20%, Hoyng said.
Patients who were older at baseline, those with CFH Y402H gene variants and those with certain phenotype characteristics, such as hyperreflective foci, central drusen location and drusenoid pigment epithelial detachment, were found to be at higher risk of progression to late-stage AMD, he said….