This drug cocktail reduced signs of age-related diseases and extended life in mice and human cells
Aging might be perfectly natural. But as practiced by the human body, it is beginning to look more and more like a disease — and a treatable one at that.
In a new study, scientists reveal aging to be a process set in motion by the rise of malign forces called senescent cells, which progressively hijack the body and take it on a nightmarish joyride. With advancing age, senescent cells take the wheel, and the human body careens into disease states ranging from cancer and diabetes to arthritis, vision loss and dementia.
As senescent cells mount, our walking pace and cognitive processing speed slow, our grips weaken and disabilities mount. Eventually, driven by this accumulation of insults, we are driven off a cliff.
The final plunge cannot be avoided. But scientists are exploring a range of tantalizing new ways to make the odyssey of sickness and frailty that precedes it a little shorter and less degrading. They may even put the cliff a bit further in the distance.
In research published Monday in the journal Nature Medicine, a group led by Mayo Clinic anti-aging researcher James Kirkland not only offers a clear look at the power of senescent cells to drive the aging process, but also a pharmaceutical cocktail that, in mice at least, can slow and even reverse it.
Even in mice who were already well along aging’s path, the senolytic cocktail — a dose of the leukemia drug dasatinib and the dietary supplement quercetin — drove down senescent cells’ numbers, tamped down the inflammation they cause, and reduced the level of disability that comes with age-related diseases.
When given to younger mice in which the aging process was jump-started with a transfer of senescent cells, the anti-aging cocktail forestalled the onset of age-related diseases. And the anti-aging effects of a single five-day course of the cocktail lasted for months, the equivalent in humans of more than a decade……
Source: Los Angeles Times