Can a supplement fight diabetic retinopathy?

The FINANCIAL — Through his years treating patients with diabetes, A. Paul Chous, O.D., has advised plenty of patients on using supplementation to slow or prevent diabetic retinopathy.
“There are so many nutrients and compounds that may play a part and have shown some success in animal models or small human trials with single nutrients,” says Dr. Chous, optometric representative to the National Diabetes Education Program of the National Institutes of Health. “We wanted to move this into something more substantial, with a multicomponent nutritional supplement.”
The result is “The Diabetes Visual Function Supplement Study,” published online in June 2015 in the British Journal of Ophthalmology. Dr. Chous and colleagues performed a 6-month randomized, controlled trial in 67 adults, all with type 1 or type 2 diabetes. Participants had either no diabetic retinopathy or mild to moderate nonproliferative diabetic retinopathy, and all had no significant differences on key study measures at baseline.
The supplement contained a mix of vitamins and nutrients tied to inhibiting retinopathy in previous work. For instance, benfotiamine, a lipid-soluble analog of vitamin B1, has been shown to shunt glucose metabolites away from the biochemical pathways involved in diabetic retinopathy. Other constituents included Pycnogenol, lipoic acid, vitamin D3, curcumin extract, and zeaxanthin and lutein.
At six months, study participants taking the supplement had better visual function (contrast and visual field sensitivity, and color vision) than those taking placebo, had improvements in serum lipid measures and hsCRP (95 percent p-values all equal to or less than 0.01), and also showed significant improvements in symptoms related to diabetic peripheral neuropathy….
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Source: Finchannel
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