Cataracts and Alzheimer’s disease linked to common gene: Study

By: Devon Andre
Cataracts and Alzheimer’s disease have been found to be linked to a common gene. Both conditions arise with age, but the latest findings now add further evidence to a genetic link, too.
The researchers looked at the brain MRIs of the participants in the Framingham Offspring Eye Study cohort. The researchers found a strong correlation between cortical cataract and Alzheimer’s disease-related brain degeneration. Particularly impacted was the volume of the temporal horn, a part of the brain which is commonly enlarged in Alzheimer’s disease. Cortical cataract was also associated with poorer performance on cognitive tests.
A genome-wide association study was also conducted looking at nearly 190,000 single-nucleotide polymorphisms (SNPs), or DNA sequence variations. The researchers uncovered three specific intronic SNPs in the gene coding of a protein essential in cell adherence and formation of connective structures.
Senior author Lindsay A. Farrer said, “Though much work remains to be done, a link between cataracts and Alzheimer’s disease supports the idea of a systemic, rather than brain-limited, focus for processes leading to Alzheimer’s disease. This study gives hope that we are moving toward earlier diagnosis and new treatment targets for this debilitating disease.”

Treating cataracts may ease Alzheimer’s symptoms

An alternative study uncovered that undergoing cataract surgery may ease Alzheimer’s disease symptoms. Lead author of the study Dr. Brigitte Girard said, “We wanted to learn whether significant vision improvement would result in positive mood and behavior changes, or might instead upset these patients’ fragile coping strategies.”
The researchers enrolled 38 men and women with mild Alzheimer’s disease, all with cataracts in at least one eye. The participants underwent cataract surgery and all of them reported great improvement in their vision……..
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Source: Bel Marra Health