Faulty immune system linked to AMD

by: Hippocratic Post

British scientists have found a link between over-active immune systems, stimulated by poor diets and oxidative stress, and the development and progression of age-related macular degeneration (AMD) – the UK’s leading cause of blindness.

Yellow deposits (known as drusen) found at the back of the eye in AMD patients contain protein covered waste products that attract and activate faulty immune cells leading to low grade but chronic inflammation and ultimately sight-threatening retinal damage, according to researchers at the University of Southampton.

Jessica L. Teeling, Professor of Experimental Neuro-immunology at the University of Southampton,one of the scientists leading research into the link between immunity and AMD explains: “We’ve found many AMD patients have over-activate immune systems. Certain diets and stress, fuel the flames of inflammation and this can lead to early onset of AMD symptoms.”

Professor Teeling continues: “In our laboratory at the University of Southampton, we measure the levels of inflammation in the blood and eyes of AMD patients and compare the levels to healthy individuals. We hope this will lead us to find a protein that can predict future vision loss and inform us about novel ways to treat this debilitating disease. We may be able to prevent or delay the symptoms of AMD if we control the immune system.”

Age-related macular degeneration is the biggest cause of blindness in the UK, affecting 600,000 people. By 2050 this number is expected to double.

Commenting on the research Cathy Yelf, CEO of the Macular Society said: “More funding into eye research is critical to help us understand how immune responses initiate or exacerbate AMD. Having a clear understanding of the role this and other environmental factors play in the disease’s development is an important stepping stone towards pinpointing novel therapeutic therapies to prevent sight loss.”…

Read more: https://www.hippocraticpost.com/ageing/faulty-immune-system-linked-to-amd/
Source: Hippocratic Post
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