Metabolic syndrome strong indicator of diabetic retinopathy
Gao L, et al. PLoS One. 2016;doi:10.1371/journal.pone.0145293.
Chinese adults are more likely to develop diabetic retinopathy if they have three or more components of metabolic syndrome, according to research in PLOS ONE.
Lu Gao, of Beijing Tongren Hospital and Capital Medical University, and colleagues analyzed data from 2,551 Chinese adults with a fasting plasma glucose of at least 5.6 mmol/L who completed the Health Examination Survey, a cross-sectional, population-based survey conducted between July 2010 and March 2011. All participants completed an oral glucose tolerance test and ophthalmic examination, including bilateral retinal photographs of the fundus through dilated pupils.
Within the cohort, 74 participants (2.9%) were diagnosed with diabetic retinopathy (mean age, 55 years; 47% women; mean HbA1c, 8.67%; 89% with diabetes); 74 patients without diabetic retinopathy were matched 1:1 by HbA1c, FPG status and time of blood draw (mean age, 55 years; 45% women; mean HbA1c, 8.67%; 85% with diabetes). Metabolic syndrome criteria included elevated glucose, abdominal obesity, hypertension, elevated triglyceride levels, low HDL cholesterol or a history of diabetes.
Researchers found no significant differences in clinical characteristics between participants with and without diabetic retinopathy. However, the percentage of participants with diabetic retinopathy increased linearly with increasing number from one to five metabolic syndrome components (14.3%, 38.9%, 49.1%, 61.4%, 83.3%, respectively). The trend to develop diabetic retinopathy in the metabolic syndrome group was higher than in the nonmetabolic syndrome group (P = .019)……..
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