Scientists used new methods to show that one type of stem cell is superior to another for treating retinal degeneration in research that could significantly advance such treatments

Source: St. Jude Children’s Research Hospital
Summary: By growing two types of stem cells in a ‘3-D culture’ and measuring their ability to produce retinal cells, a team of researchers has found one cell type to be better at producing retinal cells.

By growing two types of stem cells in a “3-D culture” and measuring their ability to produce retinal cells, a team lead by St. Jude Children’s Research Hospital researchers has found one cell type to be better at producing retinal cells.

The research not only reveals which stem cell type might be better for treating retinal degeneration, but it also demonstrates a standardized method for quantifying the effectiveness of different stem cells for such therapies.
The research was led by Michael Dyer, Ph.D., a member of the St. Jude Department of Developmental Neurobiology and a Howard Hughes Medical Institute investigator. The findings were published in the July 2 edition of the journal Cell Stem Cell.
Stem cells are immature cells that can differentiate into more specialized cells in the body. In early clinical trials, researchers are testing whether stem cells can be differentiated into cells to replace those that are defective and die off in diseases such as age-related macular degeneration, retinitis pigmentosa and Stargardt’s disease. Such degeneration is the leading cause of vision loss, affecting more than 10 million people in the U.S.–more than cataracts and glaucoma combined.
While such clinical trials have shown early promise, there are many scientific questions to be answered. “One important question is whether it makes a difference where the stem cells come from,” Dyer said. “Our research sought to explore that question and also to learn more about the biology of these stem cells.”
The researchers compared two types of stem cells called “induced pluripotent stem cells,” which can be generated from adult cells. The stem cells they compared were fibroblast-derived cells generated from skin, and those generated from mature eye cells called rod photoreceptor cells.
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