VANCOUVER, British Columbia — Human retinal progenitor cell therapy from ReNeuron Group is showing positive preliminary results in the company’s ongoing phase 1/2a clinical trial involving patients with retinitis pigmentosa.
ReNeuron chief medical officer Richard Beckman, MD, told Healio.com/OSN here at the Association for Research in Vision and Ophthalmology meeting that the three subjects in the current trial have shown subjective improvement in their visual acuity that has persisted for at least 2 months.
Study results were presented by researcher Jason Comander, MD, PhD, at the Retinal Cell and Gene Therapy Innovation Summit, held just before ARVO.
Beckman told Healio that the phase 1 portion was a dose-escalation study involving 12 patients that showed “excellent safety. We didn’t expect efficacy because these patients all had very poor vision and very little remaining retinal function.”
He noted that in phase 1, “the highest dose was transitioned into a cryopreserved formulation that’s much more commercially viable than the original fresh formulation. We now have a 9-month shelf life, and it can be shipped wherever we need it in a cryoshipper.”
The current study is being overseen at Massachusetts Eye and Ear by Comander and at the Retinal Research Institute in Phoenix by Pravin U. Dugel, MD.
The three patients with retinitis pigmentosa (RP) in this phase of the study, two in their 70s and one in their 50s, “have a little remaining visual acuity, and we’ve seen a rather remarkable, very early improvement in best corrected visual acuity on the order of about four lines of vision,” Beckman said….
Read more: https://www.healio.com/ophthalmology/retina-vitreous/news/online/%7B4b88a5be-1d77-4362-a325-f73ccc308ca8%7D/phase-2a-study-shows-improved-vision-with-stem-cell-therapy-for-retinitis-pigmentosa