The Promise of Pluripotent Stem Cells for Age Related Macular Degeneration
Pluripotent stem cells offer a new prototype for Age Related Macular Degeneration modeling and therapies.
Age-related macular Degeneration (AMD) is a eye disease characterized by degeneration of the photoreceptors in the macula, the central part of the eye. It is a one of the leading cause of the blindness in people over age 55 in the U.S. and the developed world. This condition causes impairment of central visual acuity. In normal conditions, photoreceptor cells of retina are supported metabolically and structurally by a layer of cells called Retinal Pigment Epithelial (RPE) Cells. In absence of RPE cells, photoreceptor cells degenerate and die, which is an early and critical sign of AMD. Thus, replacing dead or dying RPE cells in AMD could be a way to slow the disease process and even improve vision.
Pluripotent stem cells (PSCs), by definition, can give rise to any type of cell in the body. In one of our previous blogs we have described that patient-specific pluripotent stem cells can provide better therapeutic options for patients suffering with diabetes mellitus. Recently, it has been documented that human embryonic stem cells (HESCs) and human induced pluripotent stem cells (iPSCs) can differentiate into retinal progenitor and RPE cells. These differentiated cells mimic to human….
Source: HemaCare