The Macular Degeneration Association came across this article on current research for macular degeneration, Stargardt disease and other retina diseases. According to the article researchers have discovered that certain drug combinations can have a positive effect in preventing this eye diseases. There is still more needed research and then it will go into clinical trials. We are looking at several years before this is available though.
Researchers discover drug combination that protects against damage caused by bright light
Researchers at the Case Western Reserve University (CWRU) School of Medicine recently discovered an FDA-approved drug combination that could protect photoreceptor cells against damage caused by bright light.
The drug combination could pave the way for the prevention of macular degeneration, Stargardt disease and other vision-threatening disorders.
“Systems pharmacology is one approach to target multiple cell signaling pathways and their downstream effector proteins,” Dr. Krzysztof Palczewski, professor and chair of the department of pharmacology at Case Western Reserve University School of Medicine, said. “It can also be a way to repurpose FDA-approved medications for new indications. The key is combining low doses of medications that have distinct toxicity profiles and pharmacological properties.”
The study, conducted in mice subjects with genetic susceptibilities to retina damage, focused on a drug regimen that simultaneously stimulated and blocked G protein coupled receptors (GPCRs) sitting in nerve cell membranes. GPCRs primarily helps transmit signals in and out of cells, activating various proteins along the way.
The CWRU researchers identified 20 GPCRs that were modulated in the damaged mouse retinas……
Read more: https://lifesciencedaily.com/featured/18606-researchers-discover-drug-combination-protects-damage-caused-bright-light/
Source: Life Science Daily