Study Identifies Medium Drusen That May Signal Worsening AMD

Study findings on medium drusen: results below.
Marlene Busko
A 15-year study of more than 1300 Australian men and women who were initially free of early or late age-related macular degeneration (AMD) has shed light on the incidence and progression of medium drusen. Overall, 13.9% of the participants developed medium drusen, and older people and those with risk alleles in the CFH and ARM2 genes had a greater risk of developing medium drusen.
In addition, 5.0% of patients with medium drusen alone and 23.0% of patients with medium drusen plus retinal pigment epithelium abnormalities progressed to late-stage AMD.
“This paper sets the stage for further studies and investigations on treatments for dry AMD, and it helps us know what a given patient’s risk is, if they have so-called medium-sized drusen,” Carl D. Regillo, MD, director of Retina Service at Wills Eye Hospital and professor of ophthalmology at Thomas Jefferson University in Philadelphia, Pennsylvania, told Medscape Medical News. The key take-away message for clinicians, he said, is that patients with medium drusen plus retinal pigment epithelial abnormalities have a fourfold greater risk of progressing to a form of AMD with a risk for vision loss compared with patients with medium drusen alone.
The study, by lead author Nicole D. L. Joachim, BSc(Hons), from the Centre for Vision Research in the Department of Ophthalmology at the University of Sydney in Australia, and colleagues, was published online April 2 in JAMA Ophthalmology.
Little Known About Significance of Medium Drusen
Medium drusen (ie, intermediate soft drusen, with a maximum diameter of 63 to less than 125 μm) have not been as well studied as large drusen, soft drusen, and pigmentary lesions, Joachim and colleagues write…….
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Source: Medscape