During this process, the researchers filmed the organoids in real-time by so-called live imaging, considered as the gold standard for cell tracking.

Visual cells in the human retina may not simply die in some diseases but are mechanically transported out of the retina beforehand, according to researchers.

According to a news release, researchers from the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden have now discovered this. For their research, they used miniature human retinas produced in the laboratory, so-called organoids.

The study¹ was reported in the journal Nature Communications, with investigators noting it paves the way for completely new research approaches, especially in connection with age-related macular degeneration (AMD).

“This principle, known as cell extrusion, has not yet been studied in neurodegenerative diseases,” said Mike Karl, PhD, who heads the research group. AMD is the main cause of blindness and severe visual impairment in Germany……