Dyslipidemia is elevation of plasma cholesterol, triglycerides (TGs), or both, or a low high-density lipoprotein level that contributes to the development of atherosclerosis. Causes may be primary (genetic) or secondary. Diagnosis is by measuring plasma levels of total cholesterol, TGs, and individual lipoproteins.- Merck by:Beth SkwareckiTreating Dyslipidemia May Not Prevent Diabetic Macular Edema
Patients with diabetic macular edema (DME) tend to have elevated serum lipids, but lipid-lowering drugs may not reduce the severity of DME, according to a systematic review and meta-analysis published online July 3 in Ophthalmology.
“Our findings broadly support the view that dyslipidemia may play an important pathogenic role in the development of DME,” write Radha Das, MS, FRCS, and colleagues from the Center for Experimental Medicine at the Queen’s University Belfast in Ireland. The results on lipid-lowering drugs are, they write, “inconclusive yet intriguing.”
The review included 21 studies that evaluated DME in humans using the Early Treatment Diabetic Retinopathy Study grading protocol. A meta-analysis of the seven case-control studies, including 1125 subjects, found that total cholesterol, low-density lipoprotein cholesterol, and triglycerides were higher in patients with DME compared with in patients who had diabetes but not DME (mean serum level of total cholesterol, 30.08; 95% confidence interval [CI], 21.14 – 39.02; P < .001; mean serum level of low-density lipoprotein cholesterol, 18.62; 95% CI, 5.80 – 31.43; P < .05; mean serum level of total cholesterol, 24.82; 95% CI, 9.21 – 40.42; P < .05)………….
Read more: http://www.medscape.com/viewarticle/847752