UI research finds few side effects in new cholesterol-reduction drug class
However, the researcher says the results likely will not change the use of statins as the primary drug to reduce cholesterol levels and other cardiovascular risks.
The new class of drugs—called PCSK9 inhibitors—were studied in combination with statins to lower LDL cholesterol, or “bad cholesterol,” in high-risk patients unable to lower cholesterol levels using only statins or other lipid-lowering therapies. Statins are a class of drug often used to reduce cholesterol levels.
The study sought to address concerns about how very low levels of LDL cholesterol affect body functions that rely on cholesterol, including hormone production, digestion, and healthy cell structure.
The study appears in the Feb. 7 issue of the Journal of the American College of Cardiology, which was published online on Jan. 30.
Researchers pooled data from 14 random, controlled studies that included 5,234 patients treated with the PCSK9 drug alirocumab for up to two years. They looked for side effects in patients who achieved two or more consecutive LDL cholesterol values below a level considered to be necessary for normal cell function.
The overall incidence of side effects was similar in patients taking alirocumab versus those taking a placebo. Adverse symptoms included musculoskeletal disorders, neurologic and neurocognitive conditions (including memory impairment), and renal or liver problems. An increased incidence of diabetes was not detected, despite previous studies showing more patients than normal contracted the disease….
Read more: https://now.uiowa.edu/2017/02/ui-research-finds-few-side-effects-new-cholesterol-reduction-drug-class
Source: Iowa Now