A newly reported study, led by first author Jessie Wang, MD, found that topical therapy resulted in the closure of full-thickness macular holes in more than a third of patients; higher efficacy was seen in patients with smaller holes and in those without vitreomacular traction (VMT).¹ Wang, from the Department of Ophthalmology and Visual Science, University of Chicago Medical Center, Chicago, noted that this is the first study of the overall efficacy and clinical characteristics of successful macular hole closure using topical therapy.