When a patient with previously diagnosed neovascular age-related macular degeneration (nAMD) in 1 eye records a false negative in the fellow eye, it may actually be predictive of future conversion, a study published in Ophthalmology Retina suggests. Patients who routinely monitor their vision with ForeseeHome® (Notal Vision) and experience a false positive in the undiagnosed eye are at high risk for future conversion, according to the research.

The study included all home-monitored eyes that had a ForeseeHome alert, and conversion to nAMD was not detected within 1 month after the alert, indicating a false positive alert. For each of these eyes, the researchers obtained the iAMD vs nAMD status of the fellow eye at enrollment and eventual outcomes, including date of detection of conversion by the clinician and initiation of treatment or the date of the study final follow-up visit without a conversion.

A total of 3334 eyes of 2123 participants were included in the ALOFT study. Of those, the researchers found that 29% of eyes (n=953) had a false positive alert. Among them, 53% of eyes fellow to nAMD later converted (56/106) and 13% of eyes fellow to iAMD were fellow to iAMD and later converted (110/847).

These eyes may be candidates for prophylactic treatment studies, should be followed closely, and counseled to comply with daily home monitoring.
Source: Ophthalmology Advisor