patients with open-angle glaucoma.22 Another study showed that taking ginkgo biloba supplements appeared to improve existing visual field damage in some patients with NTG.23 A different study involving patients with NTG showed that ginkgo biloba may also have desirable effects on ocular blood flow.24

Mirtogenol (Horphag/Indena) is a dietary supplement that works similarly to ginkgo biloba. It is a combination of two phenolic extracts taken from bilberry and French maritime pine bark.25 Previous studies have demonstrated that Mirtogenol can be helpful in treating glaucoma by improving ocular blood flow and lowering IOP. In one study, Mirtogenol lowered IOP in patients with OHT who did not yet show signs of glaucoma.26 Another study noted that Mirtogenol, when used in combination with the prostaglandin analog latanoprost ophthalmic solution 0.005% (Xalatan, Viatris), had a synergistic effect; patients who received both latanoprost and Mirtogenol had significantly lower IOP and improved retinal blood flow compared with patients who took latanoprost alone.25

Resveratrol is a plant polyphenol. Clinical studies have shown that resveratrol has strong antioxidant and anti-inflammatory properties, as well as neuroprotective and anti-aging effects.27 It may also improve mitochondrial dysfunction.23 In a literature review, one study demonstrated resveratrol’s antioxidative and antiapoptotic roles in the trabecular meshwork cells by noting a decrease in inflammatory markers and cellular senescence markers consistently observed in patients with POAG.27 Another study showed that treatment with resveratrol considerably slowed the apoptotic process, helping to maintain normal mitochondrial membrane potential and enhancing cell survival.27


Dietary supplements are gaining popularity in health care. Providing our patients with information about which supplements to take can help them navigate the abundance of options out there. This list is not exhaustive, and there are many other supplements that show promise in helping to slow the onset and progression of glaucoma. Although there are limited data on nutritional supplements for glaucoma, this is an exciting area of study with a lot of future potential.

The authors would like to extend a special thank you to Zac Denning for his help in providing research sources for this article.

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